Narmafotinib (AMP-945) is an orally active inhibitor of the enzyme focal adhesion kinase (FAK, KD=0.21 nM). Narmafotinib inhibits autophosphorylation of 397Y-FAK in MDA-MB-231 cells with an IC50=7 nM and exhibits low general cellular toxicity (IC50=2.7 µM, MDA-MB-231 cells). Narmafotinib can be used for anti-cancer study[1].
Molecular Weight:
527.58
Purity:
99.86
CAS Number:
[1393653-34-3]
Formula:
C28H32F3N5O2
Target:
FAK
Application Notes:
MCE Product type: Reference compound
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