SJ10542 is a potent and selective JAK2/3 PROTAC degrader. In PDX cells lSJBALL020589, SJ10542 has DC50 values of 14 and 11 nM for JAK2 and JAK3, respectively. SJ10542 exhibits antitumor activity and can be used for the research of hematological malignancies and autoimmune diseases[1]. (Pink: Target protein ligand (HY-47073), Black: Linker (HY-W251248), Blue: E3 ligase ligand (HY-W890189), E3 ligase ligand+Linker (HY-176425))
Molecular Weight:
818.95
Purity:
99.32
CAS Number:
[2789678-92-6]
Formula:
C41H46N12O5S
Target:
JAK,PROTACs
Application Notes:
MCE Product type: Reference compound
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