DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage[1].
Molecular Weight:
555.78
Purity:
99.62
CAS Number:
[2247061-09-0]
Formula:
C30H45N5O3S
Target:
E1/E2/E3 Enzyme
Application Notes:
MCE Product type: Reference compound
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