CP-17 is a potent and selective IDH2/R140Q inhibitor with an IC50 of 40.75 nM. CP-17 exhibits excellent selectivity of >55-fold against the wild-type IDH2. CP-17 exhibits robust D-2-HG suppression activity in TF-1 (IDH2/R140Q) cells and reverses the cellular differentiation block induced by the R140Q mutation. CP-17 can be used for acute myeloid leukemia (AML) research[1].
Molecular Weight:
448.94
CAS Number:
[1111233-06-7]
Formula:
C25H25ClN4O2
Target:
Isocitrate Dehydrogenase (IDH)
Application Notes:
MCE Product type: Reference compound
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