7alpha-Hydroxy-DHEA (7alpha-Hydroxydehydroepiandrosterone) is a 7alpha-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7alpha-hydroxylases such as P450 2A1. 7alpha-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7alpha-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma[1].
Molecular Weight:
304.42
CAS Number:
[53-00-9]
Formula:
C19H28O3
Target:
Cytochrome P450,Mitochondrial Metabolism
Application Notes:
MCE Product type: Natural Products
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