ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53s transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases[1].
Molecular Weight:
640.64
CAS Number:
[2227429-65-2]
Formula:
C29H36N8O9
Target:
Apoptosis,MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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