PHGDH-IN-2 is a potent and NAD+ competitive PHGDH inhibitor with an IC50 of 5.2 µM. PHGDH-IN-2 inhibits the serine synthetic pathway in MDA-MB-468 cells. PHGDH-IN-2 inhibits the growth of PHGDH-dependent cancer cells[1].
Molecular Weight:
420.48
Formula:
C22H20N4O3S
Target:
Phosphoglycerate Dehydrogenase (PHGDH)
Application Notes:
MCE Product type: Reference compound
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