TLR7/8 antagonist 1 (Compound 16c) is a competitive TLR7/8 antagonist with IC50 values of 3.91 µM and 2.19 µM, respectively. TLR7/8 antagonist 1 reduces agonist-induced production of proinflammatory cytokines, including TNFalpha, IFNgamma and IL-1beta[1].
Molecular Weight:
417.50
CAS Number:
[2901020-63-9]
Formula:
C24H27N5O2
Target:
Interleukin Related,Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound
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