Osunprotafib (ABBV-CLS-484) is an orally active and selective active site PTPN1 (IC50: 2.5 nM) and PTPN2(IC50: 1.8 nM) inhibitor. Osunprotafib has 6-8-fold weaker activity on PTPN9 and no detectable activity on SHP-1 or SHP-2. Osunprotafib increases the sensitivity of human cancer cell lines to IFNgamma. Osunprotafib generates robust anti-tumor immunity by enhancing JAK-STAT signalling and reducing T cell dysfunction[1][2][3][4].
Molecular Weight:
385.45
Purity:
99.43
CAS Number:
[2489404-97-7]
Formula:
C17H24FN3O4S
Target:
JAK,Phosphatase,STAT
Application Notes:
MCE Product type: Reference compound
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