Osunprotafib (hydrochloride), CAS [[2986745-48-4]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-145923B
Supplier Catalog Number:
HY-145923B
Alternative Catalog Number:
MCE-HY-145923B-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
ABBV-CLS-484 (hydrochloride)
Osunprotafib (ABBV-CLS-484) hydrochloride is an orally active and selective active site PTPN1 (IC50: 2.5 nM) and PTPN2(IC50: 1.8 nM) inhibitor. Osunprotafib hydrochloride has 6-8-fold weaker activity on PTPN9 and no detectable activity on SHP-1 or SHP-2. Osunprotafib hydrochloride increases the sensitivity of human cancer cell lines to IFNgamma. Osunprotafib hydrochloride generates robust anti-tumor immunity by enhancing JAK-STAT signalling and reducing T cell dysfunction[1][2][3][4].
Molecular Weight:
421.91
CAS Number:
[2986745-48-4]
Formula:
C17H25ClFN3O4S
Target:
JAK,Phosphatase,STAT
Application Notes:
MCE Product type: Reference compound
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