alpha7 nAchR-JAK2-STAT3 agonist 1 is a potent alpha7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 µM for nitric oxide (NO). alpha7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1beta, and IL-6 in murine RAW264.7 macrophages. alpha7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-kappaB activation and cytokine production. alpha7 nAchR-JAK2-STAT3 can be used for researching sepsis[1].
Molecular Weight:
426.50
Purity:
99.54
CAS Number:
[2108714-20-9]
Formula:
C25H30O6
Target:
Interleukin Related,JAK,nAChR,NO Synthase,STAT
Application Notes:
MCE Product type: Reference compound
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