RMS5, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS5 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS5 slightly diminishes the expression of the anti-apoptotic Bcl-2 family proteins Bcl-XL and Mcl-1. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS5 has strong anticancer property[1].
Molecular Weight:
598.75
CAS Number:
[2497686-68-5]
Formula:
C35H38N2O5S
Target:
Apoptosis,P-glycoprotein
Application Notes:
MCE Product type: Reference compound
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