IRAK4-IN-14 (compound 28) is a potent, selective and orally active IRAK4 inhibitor with an IC50 of 0.003 µM. IRAK4-IN-14 shows good PK parameters in rats and mouse. IRAK4-IN-14 shows synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib[1].
Molecular Weight:
489.55
Purity:
99.01
CAS Number:
[2667681-71-0]
Formula:
C25H28FN9O
Target:
IRAK
Application Notes:
MCE Product type: Reference compound
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