PT4 is a therapeutic agent against Cutaneous leishmaniasis (CL). PT4 is effective against both species of Leishmania, with IC50s of 125.18 and 233.18 µM for L. amazonensis and L. braziliensis, respectively. PT4 decreases of mitochondrial membrane potential and increases production of reactive oxygen species, which leads to parasite death. PT4 has a potent in vivo anti-inflammatory activity[1].
Molecular Weight:
318.33
CAS Number:
[1280738-47-7]
Formula:
C18H14N4O2
Target:
Parasite,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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