PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR.PROTAC EGFR degrader 4 induces EGFRdel19 and EGFRL858R/T790M degradation with DC50s of 0.51 and 126 nM, respectively. PROTAC EGFR degrader 4 significantly inhibits growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. Induced EGFR degradation is related to autophagy[1].
Molecular Weight:
995.29
Purity:
99.70
CAS Number:
[2882845-50-1]
Formula:
C55H70N12O4S
Target:
Autophagy,EGFR,PROTACs
Application Notes:
MCE Product type: Reference compound
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