PROTAC CYP1B1 degrader-1 (Compound 6C), a alpha-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated agent resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer[1].
Molecular Weight:
785.80
Purity:
98.09
CAS Number:
[2411389-67-6]
Formula:
C43H39N5O10
Target:
Cytochrome P450,PROTACs
Application Notes:
MCE Product type: Reference compound
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