TGFbeta-IN-2 is an orally active TGF-beta inhibitor. TGFbeta-IN-2 suppresses the TGF-beta-induced protein expression of COL1A1, alpha-SMA, and p-Smad3 in vitro. TGFbeta-IN-2 demonstrates excellent anti-fibrotic efficacy in Bleomycin (HY-108345)-induced pulmonary fibrosis model. TGFbeta-IN-2 can be used for the study of pulmonary fibrosis[1].
Molecular Weight:
378.42
Purity:
99.37
CAS Number:
[2387678-02-4]
Formula:
C22H22N2O4
Target:
TGF-beta/Smad
Application Notes:
MCE Product type: Reference compound
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