Anticancer agent 58 (compound 16) has inhibitory activity against kinds of cancer cell lines, especially in A549 and T24 with IC50s of 0.6 µM and 0.7 µM, respectively. Anticancer agent 58 induces apoptosis by activating caspase 3/8/9 activity, and induces an increase of Ca2+ and ROS in cancer cells. Anticancer agent 58 significantly decreases mitochondrial membrane potential. Anticancer agent 58 can suppress tumor growth in T24 mouse xenograft model[1].
Molecular Weight:
617.86
Formula:
C39H55NO5
Target:
Apoptosis,Caspase,ROS Kinase
Application Notes:
MCE Product type: Reference compound
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