GEM-5 is a gemcitabine-based conjugate containing a HIF-1alpha inhibitor (YC-1) (IC50=30 nM). GEM-5 can significantly down-regulate the expression of HIF-1alpha and up-regulate the expression of tumor suppressor p53. GEM-5 induces the apoptosis of A2780 cells and inhibits tumor growth[1].
Molecular Weight:
649.60
CAS Number:
[2233543-49-0]
Formula:
C32H29F2N5O8
Target:
Apoptosis,HIF/HIF Prolyl-Hydroxylase,MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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