AMS-17 is a potent NLRP3 inhibitor, inhibiting microglia activation in vitro and in vivo. AMS-17 also inhibits cytokines such as caspase-1, TNF-alpha, IL-1beta and inducible nitric oxide synthase (iNOS) in N9 cells. AMS-17 can be used for researching inflammation-associated neurological disorders, such as vascular dementia (VaD)[1][2].
Molecular Weight:
386.35
Purity:
98.09
CAS Number:
[3019885-78-7]
Formula:
C15H13F3N4O3S
Target:
NOD-like Receptor (NLR)
Application Notes:
MCE Product type: Reference compound1
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