PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC50 value (1.4 µM) against PDE4 than parent rolipram (2.0 µM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS[1].
Molecular Weight:
328.35
CAS Number:
[2519450-32-7]
Formula:
C15H12N4O3S
Target:
Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound
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