BOLD-100 (NKP-1339, IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution[1].
Molecular Weight:
479.15
CAS Number:
[783324-98-1]
Formula:
C14H12Cl4N4Ru
Target:
Autophagy,HSP
Application Notes:
MCE Product type: Reference compound
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