ABN401 is an orally active and selective ATP-competitive c-MET inhibitor with an IC50 of 10 nM. ABN401 is cytotoxic to MET-addicted cancer cells with the IC50 of 2-43 nM. ABN401 has bioavailability in rats and dogs of 42.1-56.2% and 27.4-37.7%, respectively. ABN401 has antitumor activity[1][2].
Molecular Weight:
566.66
Purity:
98.82
CAS Number:
[2242563-15-9]
Formula:
C29H34N12O
Target:
Apoptosis,c-Met/HGFR
Application Notes:
MCE Product type: Reference compound
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