PKRA83 (PKRA7) is a potent prokineticin (PK2) antagonist, which can compete for the binding of PK2 to its receptors PKR1 and PKR2. PKRA83 potently inhibits PK2 receptors, with IC50 values of 5.0 nM and 8.2 nM for PKR1 and PKR2, respectively. PKRA83 has anticancer, anti-arthritis and anti-angiogenic activities. PKRA83 can penetrate the blood-brain barrier[1][2][3].
Molecular Weight:
505.02
Purity:
98.95
CAS Number:
[1233926-87-8]
Formula:
C27H34ClFN2O4
Target:
Prokineticin Receptor
Application Notes:
MCE Product type: Reference compound
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