GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids[1].
Molecular Weight:
343.38
Purity:
98.95
CAS Number:
[2351906-74-4]
Formula:
C18H21N3O4
Target:
YAP
Application Notes:
MCE Product type: Reference compound
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