LRH-1 agonist-2 (Compound 6N) is a selective, full LRH-1 agonist with an EC50 of 15.7 nM. LRH-1 agonist-2 directly interacts with the Thr352 and His390 residues in the LRH-1 binding pocket, promotes allosteric signaling to the activation function surface (AFS), stabilizes the AFS and enhances coactivator recruitment. LRH-1 agonist-2 induces the anti-inflammatory cytokine IL-10, and reduces the pro-inflammatory cytokines IL-1beta and TNFalpha. LRH-1 modulator-1 exerts anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 can be used in studies related to inflammatory bowel disease[1].
Molecular Weight:
464.66
Purity:
98.58
CAS Number:
[2244781-29-9]
Formula:
C28H36N2O2S
Target:
Interleukin Related,Orphan Nuclear Receptor
Application Notes:
MCE Product type: Reference compound
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