MYF-03-176 is an orally active inhibitor of TEAD, and suppresses TEAD transcriptional activity with an IC50 of 11 nM. The IC50 values of MYF-03-176 for TEAD1, TEAD3, and TEAD4 are 47, 32, and 71 nM, respectively. MYF-03-176 inhibits hippo signaling defective malignant pleural mesothelioma (MPM) cells. MYF-03-176 shows strong antitumor efficacy in MPM mouse xenograft model[1][2][3].
Molecular Weight:
410.37
Purity:
99.72
CAS Number:
[2857937-59-6]
Formula:
C19H18F4N4O2
Target:
YAP
Application Notes:
MCE Product type: Reference compound
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