HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKbeta-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research[1].
Molecular Weight:
419.52
Purity:
98.93
CAS Number:
[2767422-72-8]
Formula:
C24H29N5O2
Target:
Casein Kinase,IRAK,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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