Elebsiran (VIR-2218) is a siRNA that targets and degrades hepatitis B virus (HBV) and hepatitis D virus (HDV) RNA transcripts. Elebsiran leads to a significant decrease in HBV surface antigen (HBsAg) and a reduction in viral load. Elebsiran binds to the sialic acid-depleted glycoprotein receptor (ASGPR) on the surface of liver cells through the GalNAc ligand, achieving liver-targeted delivery and demonstrating improved liver safety. Elebsiran can be used for the study of chronic HBV/HDV infections[1][2][3].
Molecular Weight:
14976.67
CAS Number:
[2648009-64-5]
Formula:
C485H658N158F9O294P39S6
Target:
HBV,Small Interfering RNA (siRNA)
Application Notes:
MCE Product type: Oligonucleotides
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