Tinlorafenib (PF-07284890) is the orally active inhibitor for BRAF and CRAF with IC50s of 5.8 nM and 4.1 nM. Tinlorafenib (Compound 10) inhibits V600E mutated BRAF and V600K mutanted BRAF with IC50s of 4.25 nM and 2.7 nM. Tinlorafenib can cross the blood brain barrier. Tinlorafenib demonstrates CNS penetration and can be used in the research of BRAF-associated malignant and benign tumors of the CNS as well as extracranial malignancies[1][2].
Molecular Weight:
456.89
Purity:
98.21
CAS Number:
[2573781-75-4]
Formula:
C19H19ClF2N4O3S
Target:
ERK,Raf
Application Notes:
MCE Product type: Reference compound
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