Totrombopag is an orally effective thrombopoietin receptor (TpoR) agonist. By activating TpoR, Totrombopag initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag can be used to study platelet production and megakaryocyte biology[1].
Molecular Weight:
466.49
Purity:
99.00
CAS Number:
[376592-42-6]
Formula:
C25H22N8O2
Target:
Thrombopoietin Receptor
Application Notes:
MCE Product type: Reference compound
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