ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM[1].
Molecular Weight:
393.42
CAS Number:
[2765785-88-2]
Formula:
C20H20FN7O
Target:
ATM/ATR
Application Notes:
MCE Product type: Reference compound
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