TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1].
Molecular Weight:
453.11
CAS Number:
[2170347-69-8]
Formula:
C18H9Cl4N5O
Target:
Apoptosis,Gli,Hedgehog,Smo
Application Notes:
MCE Product type: Reference compound
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