JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQS (3D7, IC50=8.8 µM) and CQR (RKL-9, IC50=14.3 µM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent[1].
Molecular Weight:
337.42
CAS Number:
[2227315-30-0]
Formula:
C20H23N3O2
Target:
Parasite
Application Notes:
MCE Product type: Reference compound
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