MS9427 is a potent PROTAC EGFR degrader with Kds of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 potently inhibits the proliferation of NSCLC cells. MS9427 can be used for researching anticancer[1].
Molecular Weight:
993.47
Purity:
95.29
CAS Number:
[2772613-37-1]
Formula:
C48H58ClFN8O12
Target:
EGFR,PROTACs
Application Notes:
MCE Product type: Reference compound
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