MS9449 is a potent PROTAC EGFR degrader with Kds of 17 nM and 10 nM for EGFR WT and EGFR L858R, respectively. MS9449 effectively induces degradation of mutant EGFRs through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9449 potently inhibits the proliferation of NSCLC cells. MS9449 can be used for researching anticancer[1].
Molecular Weight:
1151.82
Purity:
98.95
CAS Number:
[2772612-96-9]
Formula:
C60H76ClFN10O8S
Target:
EGFR,PROTACs
Application Notes:
MCE Product type: Reference compound
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