NF-kappaB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-kappaB and MAPK pathway. NF-kappaB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 µM. NF-kappaB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ER and P38 signaling activation. NF-kappaB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-kappaB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research[1].
Molecular Weight:
477.51
Purity:
98.71
CAS Number:
[2413940-56-2]
Formula:
C27H27NO7
Target:
COX,NF-kappaB,NO Synthase,p38 MAPK
Application Notes:
MCE Product type: Reference compound
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