Talarozole (R enantiomer), CAS [[870093-23-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-14802
Supplier Catalog Number:
HY-14802
Alternative Catalog Number:
MCE-HY-14802-5MG
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
(R)-Talarozole
Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. Target: CYP26 in vitro: Talarozole R enantiomer treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1 and CYP26B1 dose dependently, and decreased theexpression of KRT2 and IL-1alpha compared with vehicle-treated skin. No mRNA change in retinol-metabolizing enzymes was obtained. There was no induction of epidermal thickness or overt skin inflammation in talarozole-treated skin. Immunofluorescence analysis confirmed an upregulation of KRT4 protein, but no upregulation of CYP26A1 and CYP26B1 expression was detected [1] [2]. in vivo: Talarozole R enantiomer slightly diffused into the skin only when dissolved in propylene glycol, isopropyl myristate or ethanol. Although only 0.1% of the dose applied was found in the skin itself after 12-24 h, this was sufficient to achieve local concentrations well above the half-maximal inhibitory concentration value for talarozole. The distribution of talarozole within the skin was investigated: 80% was located in the epidermis, while the remaining 20% was found in the dermis [3].
Molecular Weight:
377.51
Purity:
99.7
CAS Number:
[870093-23-5]
Formula:
C21H23N5S
Target:
Cytochrome P450
Application Notes:
MCE Product type: Reference compound
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