MEL23 is a MDM2 E3 ligase inhibitor that blocks the E3 ligase activity of the MDM2-MDMX complex. MEL23 inhibits Mdm2 and p53 ubiquitination in cells, reduce viability of cells with wild-type p53. MEL23 stabilizes MDM2 via a mechanism independent of p53 transcription[1].
Molecular Weight:
354.40
CAS Number:
[642072-49-9]
Formula:
C19H22N4O3
Target:
Ligands for E3 Ligase
Application Notes:
MCE Product type: Reference compound
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