Rugonersen (RG6091, RO7248824) is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch[1][2].
Molecular Weight:
6530.30
Purity:
98.50
CAS Number:
[2591587-57-2]
Formula:
C204H254N63O109P19S19
Target:
E1/E2/E3 Enzyme
Application Notes:
MCE Product type: Oligonucleotides
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