JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 µM) and reduces TNF levels (EC50=4.5 µM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases[1].
Molecular Weight:
955.08
Purity:
99.96
CAS Number:
[1254036-23-1]
Formula:
C49H63FN10O9
Target:
Complement System
Application Notes:
MCE Product type: Reference compound
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