M4K2234, a chemical probe, is an orally active, highly selective inhibitor of ALK1 and ALK2 with IC50 values of 7 nM and 14 nM, respectively. M4K2234 specifically blocks BMP signaling by inhibiting the phosphorylation of SMAD1/5/8. M4K2234 inhibits BMP7-stimulated reporter gene activity (IC50 = 16 nM). M4K2234 can be used for the investigation of ALK1/2-mediated biological processes and related diseases such as diffuse midline glioma (DMG) and fibrodysplasia ossificans progressiva (FOP)[1].
Molecular Weight:
462.56
Purity:
98.31
CAS Number:
[2421141-51-5]
Formula:
C27H31FN4O2
Target:
Anaplastic lymphoma kinase (ALK),TGF-beta/Smad
Application Notes:
MCE Product type: Reference compound
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