eIF4A3-IN-13 (compound 75) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-13 interferes the assembling of eIF4F translation complex with EC50s of 0.6, 15 and 0.4 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-13 can be used for the research of human cancer pathogenesis[1].
Molecular Weight:
509.98
Purity:
99.92
CAS Number:
[1402931-85-4]
Formula:
C28H28ClNO6
Target:
Eukaryotic Initiation Factor (eIF)
Application Notes:
MCE Product type: Reference compound
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