VU6019650 is a potent and selective orthosteric antagonist of M5 mAChR (IC50=36 nM), can be used for opioid use disorder (OUD) relief. VU6019650 can cross blood brain barrier, potentially modulates the mesolimbic dopaminergic reward circuitry. VU6019650 blocks Oxotremorine M iodide (HY-101372A) induced increases of neuronal firing rates of midbrain dopamine neurons in the ventral tegmental area (VTA)[1][2].
Molecular Weight:
411.51
Purity:
98.01
CAS Number:
[2926782-31-0]
Formula:
C18H22FN3O3S2
Target:
mAChR
Application Notes:
Reference compound
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