Tafamidis is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 µM. Tafamidis inhibits amyloidogenesis[1].
Molecular Weight:
308.12
Purity:
99.89
CAS Number:
[594839-88-0]
Formula:
C14H7Cl2NO3
Target:
Endoplasmic Reticulum Oxidoreductase 1 (ERO1)
Application Notes:
Reference compound
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