GDC-0134 (RG6000) is a modulator targeting dual leucine zipper kinase (DLK) that can cross the blood-brain barrier. By inhibiting the kinase activity of DLK, GDC-0134 blocks the activation of the downstream JNK signaling pathway, suppresses DLK-dependent retrograde signal transduction of axon-to-soma degeneration, and exerts neuroprotective activity. GDC-0134 reduces TDP-43 protein aggregation and decreases the degree of neuromuscular junction denervation in motor neurons. GDC-0134 can be used in the research of amyotrophic lateral sclerosis (ALS), Alzheimers disease and other DLK-related neurodegenerative diseases[1].
Molecular Weight:
440.39
Purity:
99.18
CAS Number:
[1637394-01-4]
Formula:
C19H20F4N6O2
Target:
JNK
Application Notes:
MCE Product type: Reference compound
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