AK-2292 is a potent and selective STAT5 PROTAC degrader, with a DC50 of 0.10 µM. AK-2292 induces degradation of STAT5A/B proteins in vitro and in vivo. AK-2292 can induce tumor regression in acute myeloid leukemia and chronic myeloid leukemia xenograft mouse models[1][2]. AK-2292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Molecular Weight:
1070.13
Purity:
99.73
CAS Number:
[2984506-77-4]
Formula:
C52H54F2N7O10PS2
Target:
PROTACs,STAT
Application Notes:
MCE Product type: Reference compound1
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