MS40 is a WDR5 PROTAC degrader (Kd = 125 nM). MS40 promotes the ubiquitination and degradation of WDR5. MS40-induced WDR5 degradation leads to the dissociation of the MLL/KMT2A complex from chromatin, resulting in decreased H3K4me2 levels. MS40 can be used in the study of primary leukemia[1].
Molecular Weight:
995.10
CAS Number:
[2407449-49-2]
Formula:
C52H61F3N10O7
Target:
WDR5
Application Notes:
MCE Product type: Reference compound
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