SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes[1].
Molecular Weight:
348.40
Purity:
99.80
CAS Number:
[2727872-68-4]
Formula:
C19H20N6O
Target:
HuR
Application Notes:
MCE Product type: Reference compound1
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