STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. STAT3-IN-11 inhibits the phosphorylation of downstream genes (Survivin and Mcl-1) without affecting its upstream tyrosine kinases (Src and JAK2) levels and p-STAT1 expression. STAT3-IN-11 can induce cancer cell apoptosis, which is potential for the discovery of effective STAT3 inhibitors and antitumor agents against cancers[1].
Molecular Weight:
335.35
Purity:
98.29
CAS Number:
[2503096-50-0]
Formula:
C20H17NO4
Target:
Apoptosis,STAT
Application Notes:
MCE Product type: Reference compound
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